Northrop, John H. | Crystalline Enzymes. The Chemistry of Pepsin, Trypsin, and Bacteriophage

  • First edition, first printing. Presentation copy inscribed by the author on the front free endpaper, “To Professor Gunnar Holmgren [?] with the compliments of John H. Northrop”. The recipient’s name is unclear, but may have been the otolaryngologist Gunnar Holmgren who died in 1954.

    Northrop, together with Wendell Meredith Stanley, was awarded the Nobel Prize in 1946 “for their preparation of enzymes and virus proteins in a pure form”. The award was also shared that year with James Batcheller Sumner, who had originally discovered that enzymes can be crystallised. Northrop’s pioneering work “made possible detailed studies of the chemical nature of enzymes, and as chemists could not use well-defined enzyme preparations they were able to investigate the changes brought about by these substances in a far more systematic way than before and with far greater chances of success” (Nobel, the Man and His Prizes, p. 377). Books inscribed by Northrop are uncommon, and this is a particularly attractive copy of his key book, for which he was awarded the Daniel Giraud Elliot Medal by the National Academy of Sciences.

  • New York: Columbia University Press, 1939.

    Octavo. Original blue cloth, titles to spine gilt. Cloth lightly rubbed at the extremities. An excellent copy.