History & Philosophy of Science
(Brenner, Sydney) Douarin, Nicole le | Dans le Secret des Êtres Vivants
£250.00
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First edition, first impression, paperback issue. Presentation copy inscribed by the author to Nobel Prize-winning biologist Sydney Brenner on the half title, “It has been great to have the chance to know you. Thanks to Gulbenkian! With my admiration and my sincére amitié, these pages about my life in science. Paris, le 26 Juillet 2012, Nicole le Douarin”. Gulbenkian probably refers to the Calouste Gulbenkian Foundation, a philanthropic organisation which may have held a conference or other event at which Douarin and Brenner met.
Recipient Sydney Brenner (1927 - ) has been a leader in the field of genetics almost from the moment he received his doctorate at Oxford in 1954. He joined Francis Crick’s laboratory in 1956, and they did groundbreaking research on how DNA is decoded by cells. Brenner proposed that the nucleotides which comprise DNA (adenine, guanine, thiamine and cytosine) are read by the cell in sets of three called codons, with each codon representing an amino acid (for example, three adenines in a row is the codon for the amino acid lysine). A gene is simply a string of codons that directs the production of a protein molecule from individual amino acids. He also correctly predicted the existence of messenger RNA, the molecule that carries the genetic code from the nucleus to the ribosomes, where the translation process occurs.
Following this work, it was Brenner’s efforts to establish a new laboratory organism for the study of genetics that led to his Nobel Prize. “Beginning in 1965, he began to lay the groundwork to make C. elegans, a small, transparent nematode, into a major model organism for genetics, neurobiology and developmental biology research. As a direct result of his original vision, this tiny worm became the first animal for which the complete cell lineage and entire neuronal wiring were known. Today, more than 1,000 investigators are studying C. elegans, and Brenner’s work was further honored when a closely related nematode was named Caenorhabditis brenneri” (Salk Institute biography).
Author Nicole le Douarin (1930 - ) is a leader in the field of developmental biology. She has designed important techniques for studying differentiation in embryos, most importantly the creation of chimeras in which cells from two different species can be individually tracked as they develop into organ systems. Crucially, she used this technique to elucidate the early development of the nervous and immune systems. Douarin has recieved numerous accolades for her work. “In 1988 she was only the third woman in 500 years to be admitted as a member of the College de France. In 1989 she was elected as a member of the US National Academy of Science and in 1990 as a fellow of the Royal Society. She also received the Louis-Jeantet Prize for Medicine in 1990 and in 1991 she became an officer of the Légion d’Honneur. In 1993 she received the Louisa Gross Horwitz Prize from Columbia University. She is an honorary fellow of the Academy of Medical Sciences (2002) and was the first recipient of the Pearl Meister Greengard Prize for women in science and biology (2004)” (The Embryo Project Encyclopedia).
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...Itinéraire d'une Biologiste. Péreface de Mona Ozouf et Michelle Perrot.
Paris: Robert Laffont, 2012.
Pefect bound. Original white wrappers printed in blue and black. With the publisher’s wraparound band. Minor bump to head of spine. An excellent, fresh copy.
(Brenner, Sydney) Todd, Alexander | A Time to Remember. The Autobiography of a Chemist
£450.00
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First edition, first impression. From the library of Nobel Prize-winning biologist Sydney Brenner, presentation copy inscribed from the author to Brenner on the front blank, “With respect and warmest wishes, Alexander Todd, 24th May 1984”.
The author, biochemist Alexander Todd (1907-1997), was awarded the Nobel Prize in chemistry in 1957 “for his work on the synthesis of nucleotides (the small units that make up the larger molecule of nucleic acids), the hereditary material of cells. This work led to many important advances in chemistry and biochemistry”, including the elucidation of the structure of DNA by Watson and Crick (Shampo, “Alexander Todd”, Mayo Clinic Proceedings, March 2012).
Recipient Sydney Brenner was a leader in the field of genetics almost from the moment he received his doctorate at Oxford in 1954. He joined Francis Crick’s laboratory in 1956, and they did groundbreaking research on how DNA is decoded by cells. Brenner proposed that the nucleotides which comprise DNA (adenine, guanine, thiamine and cytosine) are read by the cell in sets of three called codons, with each codon representing an amino acid (for example, three adenines in a row is the codon for the amino acid lysine). A gene is simply a string of codons that directs the production of a protein molecule from individual amino acids. He also correctly predicted the existence of messenger RNA, the molecule that carries the genetic code from the nucleus to the ribosomes, where the translation process occurs.
Following this work, it was Brenner’s efforts to establish a new laboratory organism for the study of genetics that led to his Nobel Prize. “Beginning in 1965, he began to lay the groundwork to make C. elegans, a small, transparent nematode, into a major model organism for genetics, neurobiology and developmental biology research. As a direct result of his original vision, this tiny worm became the first animal for which the complete cell lineage and entire neuronal wiring were known. Today, more than 1,000 investigators are studying C. elegans, and Brenner’s work was further honored when a closely related nematode was named Caenorhabditis brenneri” (Salk Institute biography).
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Cambridge: Cambridge University Press, 1983.
Octavo. Original blue cloth, titles to spine in silver. With the dust jacket. Remnants of a price sticker to the front flap of the jacket. Lower corner bumped. An excellent copy in the lightly rubbed jacket that is a little faded along the spine panel.
(Gould, Stephen Jay) Mitchell, W. J. T. | The Last Dinosaur Book
£200.00
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First edition, first printing. Presentation copy inscribed by the author to palaeontologist Stephen Jay Gould on the front free endpaper, “For Steven [sic], This was written to you. Warm regards, Tim Mitchell”. Loosely inserted is a bookmark promoting Gould’s talk “Pattern and Lack of Progress in the History of Life”, the keynote lecture for Dinofest International 1996.
The Last Dinosaur Book was the first comprehensive, critical enquiry into the depiction of dinosaurs in popular culture, revealing “a cultural symbol whose plurality of meaning and often contradictory nature is emblematic of modern society itself”. Author W. J. T. Mitchell is a professor of English literature and art history at the University of Chicago. “A scholar and theorist of media, visual art, and literature, Mitchell is associated with the emergent fields of visual culture and iconology (the study of images across the media). He is known especially for his work on the relations of visual and verbal representations in the context of social and political issues” and is editor of the journal Critical Inquiry and the recipient of a Guggenheim Fellowship (University of Chicago biography).
Recipient Stephen Jay Gould (1941-2002) was one of the leading evolutionary biologists of the 20th century. His theory of punctuated equilibria challenged the idea that evolution is a slow and constant accumulation of changes, pointing out that instead it often occurs in rapid bursts of speciation followed by periods of stasis. He was a prominent defender of teaching evolution in schools and a leading critic of the field of sociobiology, which he saw as providing a pseudoscientific basis for discrimination. But he was best known as a popular science writer, penning three hundred essays that were originally published in Natural History Magazine.
Gould is cited in the text several times, on the “archetypal fascination” of dinosaurs as “alluringly scary, but sufficiently safe” because of their extinction; on their commercialisation turning them from “sources of awe into clichés and commodities”; and on contemporary scientific disputes about dinosaur biology and evolution.
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...The Life and Times of a Cultural Icon. Chicago & London: The University of Chicago Press, 1998.
Octavo. Original blue cloth, titles to spine in copper, blue endpapers. With the dust jacket. Colour illustrations throughout. Just a tiny spot of delamination at the lower edge of the jacket. An excellent, fresh copy.
(Gould, Stephen Jay) Wilford, John Noble | The Riddle of the Dinosaur
£250.00
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First edition, first printing. Presentation copy inscribed by the author on the half title, “To Stephen Jay Gould, Many thanks for the inspiration of your essays. Best wishes, John Noble Wilford”.
A lovely copy of this popular account of recent developments in dinosaur palaeontology, including the discoveries that they were likely warm-blooded and that a comet probably caused their extinction, by Pulitzer Prize-winning New York Times journalist John Noble Wilford (1933 - ). Wilford was responsible for the paper’s front-page story on the Apollo 11 Moon landing in 1969, and his by-line was the only one that appeared on the front page that day. Stephen Dubner, co-author of Freakonomics, described one of the sentences in the Moon landing piece – describing Armstrong’ heart-rate during the descent to the surface – as “one of the most elegant little uses of data I can recall seeing in a news article” (Dubner, “When Data Tell the Story”, Freakonomics blog, July 21, 2009).
Recipient Stephen Jay Gould (1941-2002) was one of the leading evolutionary biologists of the 20th century. His theory of punctuated equilibria challenged the idea that evolution is a slow and constant accumulation of changes, pointing out that instead it often occurs in rapid bursts of speciation followed by periods of stasis. He was a prominent defender of teaching evolution in schools and a leading critic of the field of sociobiology, which he saw as providing a pseudoscientific basis for discrimination. But he was best known as a popular science writer, penning three hundred essays that were originally published in Natural History Magazine. In 1991 Wilford reviewed Gould’s fifth essay collection, Bully for Brontosaurus, calling its contents “provocative and delightfully discursive”.
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...Drawings by Douglas Henderson. New York: Alfred A. Knopf, 1985.
Quarto. Original grey boards, cream cloth backstrip, titles to spine and author’s name to upper board in gilt and copper. With the dust jacket. 6 colour plates, illustrations and charts within the text. An excellent copy in the jacket with just a couple of miniscule rubbed spots and faint toning along the upper edges.
Wootton, Barbara | In a World I Never Made
£150.00
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Second impression. Presentation copy inscribed by the author on the front free endpaper, “Ted Willis, with love, B. W., December 1976” and additionally signed by the author on the title.
Wootton (1897-1988) was a prominent, left-leaning London University sociologist and economist who, in addition to her respected academic work, “served on four royal commissions and innumerable committees, was a governor of the BBC, and was a magistrate for forty years” (Ogilvie, Biographical Dictionary of Women in Science, p. 1400). “One of her most important academic works was published in 1959 and resulted from five years of research. In this work she reversed commonly accepted ideas about the criminal personality, juvenile delinquency, inherited behaviour trends, and problems of illegitimacy” (Ogilvie, p. 1400).
While the identify of the recipient is not known for sure, it may have been Baron Willis (1914-1992), the playwright, screenwriter, and active supporter of the Labour Party who was made a life peer just a few years after Wootton.
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...Autobiographical Reflections. London: George Allen & Unwin Ltd, 1967.
Octavo. Original green cloth, titles to spine gilt on black ground, With the dust jacket. Small black mark to the cloth of the upper board, a few light spots to the edges of the text block. A very good copy in the rubbed, creased, and price-clipped jacket with a few small spots on the lower panel and an over-price sticker on the front flap.